SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC)

• Sinonimo/i: (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride
• Formula empirica (notazione di Hill): C₁₂H₁₄N₄O₃ · HCl
• Numero CAS: 120964-45-6
• Peso molecolare: 298.73
• Numero MDL: MFCD18782644
• Codice UNSPSC: 12352200
• ID PubChem: 329825310
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Stato: powder
• Attività ottica: [α]/D -88 to -108°, c = 0.1 in water
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: ≥5 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1; UNSKMHKAFPRFTI-FDKLLANESA-N

Descrizione

Descrizione generale

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Applicazioni

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

Azioni biochim/fisiol

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

3-Deazaneplanocin A is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable