Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• Formula empirica (notazione di Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Numero CAS: 6119-47-7
• Peso molecolare: 396.91
• Numero CE: 205-001-1
• Numero MDL: MFCD00078498
• Codice UNSPSC: 12352210
• ID PubChem: 57654577
• NACRES: NA.77

Proprietà

• product name: Quinine hydrochloride dihydrate,
• Livello qualitativo: 200
• Solubilità: H₂O: 0.25/5 g/mL, clear, colorless
• Spettro attività antibiotica: parasites
• Modalità d’azione: enzyme | inhibits
• Stringa SMILE: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1; SGVZDMWHXVXUBY-HZQSTTLBSA-N

Descrizione

Descrizione generale

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

Applicazioni

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

Azioni biochim/fisiol

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.

Potassium channel blocker

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H317,H334
• Consigli di prudenza: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves