22632

Quinine hydrochloride dihydrate

tested according to Ph. Eur.

• Sinonimo/i: Chinini hydrochloridum, (8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate
• Formula empirica (notazione di Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Numero CAS: 6119-47-7
• Peso molecolare: 396.91
• Beilstein: 6112655
• Numero CE: 205-001-1
• Numero MDL: MFCD00151248
• Codice UNSPSC: 12352210
• ID PubChem: 329752329
• NACRES: NA.25

Proprietà

• agenzia: USP/NF; tested according to Ph. Eur.
• Livello qualitativo: 100
• Forma fisica: solid
• Solubilità: water: soluble 0.25 mg in 5 ml
• applicazioni: pharmaceutical (small molecule)
• Stringa SMILE: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1; MPQKYZPYCSTMEI-FLZPLBAKSA-N

Descrizione

Applicazioni

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy. It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.

Azioni biochim/fisiol

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H317,H334
• Consigli di prudenza: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves