P9129

5-Pregnen-3β-ol-20-one

≥98%

• Sinonimo/i: 3β-Hydroxy-5-pregnen-20-one, Pregnenolone
• Formula empirica (notazione di Hill): C₂₁H₃₂O₂
• Numero CAS: 145-13-1
• Peso molecolare: 316.48
• Beilstein: 2059026
• Numero CE: 205-647-4
• Numero MDL: MFCD00003628
• Codice UNSPSC: 12352211
• ID PubChem: 24899008
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98%
• Forma fisica: powder
• Solubilità: ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow
• Gruppo funzionale: ketone
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
• InChI: 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1; ORNBQBCIOKFOEO-QGVNFLHTSA-N
• Informazioni sul gene: human ... SERPINA6(866) ; rat ... Ar(24208)

Descrizione

Applicazioni

5-Pregnen-3β-ol-20-one is suitable for use:

• as a substrate for 3β-HSD at a concentration of 1 μg/mL to study the time-dependent effect of reduced oxygen tension on 3β-hydroxysteroid dehydrogenase (3β-HSD) activity
• as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells
• in the testicular interstitial cell culture medium at a concentration of 15mg/mL

Azioni biochim/fisiol

One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.

Testosterone production in rats occurs in Leydig cells of the testis via the Δ⁴ pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone. Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with γ-aminobutyric acid (GABA) receptor.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)