P5248
Etidronate disodium hydrate
≥97% (NMR), solid
Sinonimo/i:
Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
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About This Item
Formula empirica (notazione di Hill):
C2H6Na2O7P2 · xH2O
Numero CAS:
Peso molecolare:
249.99 (anhydrous basis)
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥97% (NMR)
Stato
solid
Colore
white
Punto di fusione
>300 °C
Solubilità
H2O: ≥10 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
GWBBVOVXJZATQQ-UHFFFAOYSA-L
Applicazioni
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
Azioni biochim/fisiol
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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