P4005
Protamine
solid
Sinonimo/i:
Protamine
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About This Item
Prodotti consigliati
Nome del prodotto
Protamine from salmon, Grade IV, Histone, free(Millon test)
Origine biologica
fish (salmon)
Livello qualitativo
Tipo
Grade IV
Stato
solid
Impurezze
Histone, free (Millon test)
Solubilità
H2O: soluble, clear to slightly hazy, colorless to faintly yellow
Temperatura di conservazione
−20°C
Descrizione generale
Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.
Applicazioni
Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.
Azioni biochim/fisiol
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamines are found to displace histones in DNA during spermatogenesis in animals and plants. Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin
British Journal of Haematology, 152(1), 99-107 (2011)
Adsorption characteristics of various proteins on a metal surface in the presence of an external electric potential
Colloids and Surfaces, B: Biointerfaces, 262-268 (2018)
Protamine and protamine reactions
International Anesthesiology Clinics, 42(3), 135-145 (2004)
The EMBO journal, 40(13), e103311-e103311 (2021-05-13)
Due to their capability to transport chemicals or proteins into target cells, cell-penetrating peptides (CPPs) are being developed as therapy delivery tools. However, and despite their interesting properties, arginine-rich CPPs often show toxicity for reasons that remain poorly understood. Using
The protamine family of sperm nuclear proteins
Genome Biology, 8(9), 227-227 (2007)
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