P1645

Palmitoyl-L-carnitine chloride

≥98% (TLC), powder

• Sinonimo/i: O-Palmitoyl-L-carnitine chloride
• Formula condensata: C₂₃H₄₆NO₄ · Cl
• Numero CAS: 18877-64-0
• Peso molecolare: 436.07
• Beilstein: 4071005
• Numero CE: 242-642-6
• Numero MDL: MFCD00070346
• Codice UNSPSC: 12352211
• ID PubChem: 24898229
• NACRES: NA.25

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Stato: powder
• Colore: white
• Solubilità: H₂O: 25 mg/mL (with heat or sonication)
• Tipo di lipide: saturated FAs
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
• InChI: 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1; GAMKNLFIHBMGQT-ZMBIFBSDSA-N

Descrizione

Applicazioni

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).

Azioni biochim/fisiol

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves