M7316
Monoamine Oxidase A human
recombinant, expressed in baculovirus infected BTI insect cells
Sinonimo/i:
MAO-A, MAOA
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About This Item
Numero MDL:
Codice UNSPSC:
12352204
NACRES:
NA.54
Prodotti consigliati
Ricombinante
expressed in baculovirus infected BTI insect cells
Livello qualitativo
Stato
liquid
Confezionamento
vial of ~2.5 mg
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... MAOA(4128)
Descrizione generale
Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.
Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.
Applicazioni
Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.
Azioni biochim/fisiol
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Dale E Edmondson et al.
Neurotoxicology, 25(1-2), 63-72 (2003-12-31)
The structural details of the interactions of the covalent 8alpha-S-cysteinyl-FAD with the protein moiety in monoamine oxidase B (MAO B) based on the MAO B crystal structure are described. The dinucleotide is bound to the protein in an extended conformation
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Kenneth I Shulman et al.
CNS drugs, 27(10), 789-797 (2013-08-13)
This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as phenelzine, tranylcypromine and isocarboxazid, as well as the second generation selective and reversible MAOIs such as the MAO-A inhibitor, moclobemide and
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