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M3778

Sigma-Aldrich

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

≥97% (GC)

Sinonimo/i:

Clorgyline

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About This Item

Formula empirica (notazione di Hill):
C13H15Cl2NO · HCl
Numero CAS:
17780-75-5
Peso molecolare:
308.63
Numero CE:
241-760-5
Numero MDL:
MFCD00052012
Codice UNSPSC:
12352116
ID PubChem:
24278179
NACRES:
NA.77

Saggio

≥97% (GC)

Forma fisica

powder

Solubilità

DMSO: 10 mg/mL, clear, colorless to faintly yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

InChI

1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H
BBAZDLONIUABKI-UHFFFAOYSA-N

Informazioni sul gene

human ... MAOA(4128)
rat ... Maoa(29253) , Maob(25750)

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Applicazioni

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
  • in MAO-A biochemical assay
  • to study its effects on the transit of serotonin (5-HT) in the human placenta explants
  • to study its effects on human prostate cancer cells

Azioni biochim/fisiol

MAO-A inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H312 + H332

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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J C Shih et al.
Journal of neural transmission. Supplementum, 52, 1-8 (1998-06-13)
MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and
Tamara Maes et al.
Cancer cell, 33(3), 495-511 (2018-03-06)
The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic
Toshiaki Shinka et al.
Oncology letters, 2(2), 211-215 (2011-03-01)
Prostate cancer is one of the most common tumors in males and its incidence is steadily increasing worldwide. Serotonin or 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter that mediates a wide variety of physiological effects. An increase in the number of
H Inoue et al.
The Journal of pharmacology and experimental therapeutics, 291(2), 856-864 (1999-10-19)
In an attempt to provide a better understanding of the scope and limitations of animal models used in some drug development programs and to further our understanding of potential metabolic bioactivation reactions, we have undertaken studies to profile the monoamine
Melissa D'Ascenzio et al.
Journal of enzyme inhibition and medicinal chemistry, 30(6), 908-919 (2015-03-26)
Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B
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