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M3445

Sigma-Aldrich

Magnolol

≥90% (HPLC), from plant

Sinonimo/i:

2,2′-Bichavicol, 5,5′-Diallyl-2,2′-biphenyldiol

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About This Item

Formula empirica (notazione di Hill):
C18H18O2
Numero CAS:
528-43-8
Peso molecolare:
266.33
Numero MDL:
MFCD00016658
Codice UNSPSC:
12352100
ID PubChem:
24896843
NACRES:
NA.25

Origine biologica

plant

Livello qualitativo

200

Saggio

≥90% (HPLC)

Solubilità

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
fungi

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Modalità d’azione

cell membrane | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
VVOAZFWZEDHOOU-UHFFFAOYSA-N

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Descrizione generale

Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound.

Applicazioni

Magnolol has been used:
  • to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model
  • to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay
  • to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains
  • in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies

Azioni biochim/fisiol

Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.
Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Avvertenze

Danger

Indicazioni di pericolo

H315,H318,H335,H411

Classi di pericolo

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
059M4892V
SLCB0101
SLBW6071
SLBV0259
SLBP7103V

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Sigma-Aldrich

413526

2,2′-Diallylbisphenol A

(−)-Epigallocatechin gallate ≥95%

Sigma-Aldrich

E4143

(−)-Epigallocatechin gallate

(−)-Catechin ≥97% (HPLC), from green tea

Sigma-Aldrich

C0567

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Resveratrolo ≥99% (HPLC)

Sigma-Aldrich

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Curcumin from Curcuma longa (Turmeric), powder

Sigma-Aldrich

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Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Abhishek Manoj Ranaware et al.
International journal of molecular sciences, 19(8) (2018-08-15)
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will
Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Yong Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3526-3530 (2013-03-13)
Magnolol is one of main active constituents from Magnolia officinalis, a widely used traditional Chinese medicine. Previous studies have proved its multiple pharmacological effects, such as anti-oxidation, anti-microbial and anti-tumor. In recent years, more and more studies have focused on
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