384620

Honokiol

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

• Sinonimo/i: Honokiol, 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
• Formula empirica (notazione di Hill): C₁₈H₁₈O₂
• Numero CAS: 35354-74-6
• Peso molecolare: 266.33
• Numero MDL: MFCD00016674
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Descrizione: Merck USA index - 14, 4742
• Saggio: ≥98% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 10 mg/mL; ethanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Oc1c(cc(cc1)c2c(ccc(c2)CC=C)O)CC=C
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2; FVYXIJYOAGAUQK-UHFFFAOYSA-N

Descrizione

Descrizione generale

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.

The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Anti-angiogenic, anti-tumor and anxiolytic properties

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Bai, X., et al. 2003. J. Biol. Chem.278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H318,H411
• Consigli di prudenza: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Classi di pericolo: Aquatic Chronic 2 - Eye Dam. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable