L5163

Latrunculin A

from sea sponge, ≥85% (HPLC), waxy solid

• Sinonimo/i: LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
• Formula empirica (notazione di Hill): C₂₂H₃₁NO₅S
• Numero CAS: 76343-93-6
• Peso molecolare: 421.55
• Codice UNSPSC: 12352200
• ID PubChem: 329817620
• NACRES: NA.77

Proprietà

• Origine biologica: sea sponge
• Livello qualitativo: 200
• Saggio: ≥85% (HPLC)
• Forma fisica: waxy solid
• PM: 421.6
• Solubilità: DMSO: soluble; ethanol: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1
• InChI: 1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1; DDVBPZROPPMBLW-IZGXTMSKSA-N

Descrizione

Descrizione generale

Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin. It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.

Applicazioni

Latrunculin A has been used as medium supplementation for A549 cells to determine the internalization mechanism of CAV9 in A549 human lung carcinoma cells.

Azioni biochim/fisiol

Latrunculin A inhibits actin polymerization by a different mechanism than cytochalasins. Latrunculin A disrupts microfilament-mediated processes.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)