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Key Documents

Altri documenti

C8273

Sigma-Aldrich

Cytochalasin D

from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

Sinonimo/i:

Lygosporin A, Zygosporin A

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About This Item

Formula empirica (notazione di Hill):
C30H37NO6
Numero CAS:
22144-77-0
Peso molecolare:
507.62
Beilstein:
1632828
Numero CE:
244-804-1
Numero MDL:
MFCD00077706
Codice UNSPSC:
12352200
ID PubChem:
24893039
NACRES:
NA.77

Origine biologica

Zygosporium mansonii

Livello qualitativo

300

Saggio

≥98% (TLC and HPLC)

Forma fisica

powder

Solubilità

DMSO: soluble
ethanol: soluble

Spettro attività antibiotica

fungi

Modalità d’azione

DNA synthesis | interferes

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
SDZRWUKZFQQKKV-JHADDHBZSA-N

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Descrizione generale

Cytochalasin D (CytoD) is commonly used to inhibit actin dynamics and study its role in cellular processes. This fungal-derived small organic compound acts as an inhibitor of the interaction between G-actin and cofilin by binding to G-actin. Additionally, CytoD inhibits the binding of cofilin to F-actin and reduces the rate of actin polymerization and depolymerization in living cells.
Cytochalasin D is a cell-permeable fungal toxin. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Cytochalasin D inhibits smooth muscle contraction and insulin-stimulated but not basal transport of glucose.

Applicazioni

Cytochalasin D has been used:
  • to treat H9c2 cells to study the relationship between cell stiffness and the F-actin cytoskeleton
  • as inhibitor of receptor-mediated endocytosis to treat oligodendrocyte precursor cells (OPCs) to investigate the effect of inhibiting specific extracellular vesicle (EV) uptake pathways
  • in in vitro embryo culture to artificially activate oocytes

Azioni biochim/fisiol

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Prodotti correlati

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Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300

Classi di pericolo

Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Integrative biology : quantitative biosciences from nano to macro, 7(3), 298-312 (2015-01-23)
During development and in adult tissues separation of phenotypically distinct cell populations is necessary to ensure proper organization and function of tissues and organs. Various phenomena, such as differential adhesion, differential mechanical tension and cell-cell repulsion, are proposed to cause
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