L3382
Lectin from Helix pomatia
lyophilized powder, salt, free
Sinonimo/i:
Helix pomatia agglutinin, HPA
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Forma fisica
lyophilized powder
Livello qualitativo
Potenza
<4 μg per mL agglutination activity
Impurezze
salt, free
Temperatura di conservazione
−20°C
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Categorie correlate
Descrizione generale
Lectin from Helix pomatia is a hexameric glycoprotein with a molecular mass of 79 kDa. It issecreted by the albumen gland of the roman snail. Helix pomatia agglutinin (HPA) is specific for N-acetylgalactosamine (GalNAc).
Applicazioni
Lectin from Helix pomatia has been used to conjugate with biotin and acridinium and used in lectin-agglutination tests.
Azioni biochim/fisiol
Lectin from Helix pomatia protects fertilized eggs by coating them with perivitelline fluid. They exhibit antibacterial activities and immunity in snail. Helix pomatia agglutinin (HPA) possess the potential to agglutinate pathogens. HPA has also emerged as a marker of altered Oglycosylation in cancer.
HPA has anti-A human blood group specificity and has an affinity for terminal N-acetyl-α-D-galactosaminyl residues. Conjugates are prepared from affinity purified lectin.
Nota sulla preparazione
Affinity purified by a modification of the method of Hammarstrom and Kabat.
Risultati analitici
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human blood group A erythrocytes after 1 hour incubation at 25 °C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Hammarstrom, S., and Kabat, E.A.
Biochemistry, 95, 311-311 (1978)
Biochemical and structural analysis of helix pomatia agglutinin a hexameric lectin with a novel fold
Sanchez JF, et al.
The Journal of biological chemistry, 281(29), 20171-20180 (2006)
Binding of aberrant glycoproteins recognizable by Helix pomatia agglutinin in adrenal cancers
Parameswaran R, et al.
BJS open, 2(5), 353-359 (2018)
Katie Barr et al.
Transfusion, 55(1), 129-136 (2014-07-22)
The FORS blood group system (originally recognized as the Apae phenotype) was discovered by sporadic activity against polyclonal anti-A reagents and activity against the lectin Helix pomatia. The extent of monoclonal anti-A reagent activity against the FORS1 antigen is serologically
Characterization of bovine and human group B streptococci isolated in Turkey
Ekin IH and Gurturk K
Journal of Medical Microbiology, 55(5), 517-521 (2006)
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