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L2131

Sigma-Aldrich

1-Stearoyl-sn-glycero-3-phosphocholine

≥99%, powder

Sinonimo/i:

L-α-Lysophosphatidylcholine, stearoyl, Lysolecithin, stearoyl

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About This Item

Formula empirica (notazione di Hill):
C26H54NO7P
Numero CAS:
19420-57-6
Peso molecolare:
523.68
Numero MDL:
MFCD00050427
Codice UNSPSC:
51191904
ID PubChem:
24896302
NACRES:
NA.25

Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥99%

Forma fisica

powder

Colore

white

Gruppo funzionale

phospholipid

Tipo di lipide

phosphoglycerides

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O

InChI

1S/C26H55NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h25,28H,5-24H2,1-4H3,(H,30,31)
ARQYPVZFUYHQFR-UHFFFAOYSA-N

Applicazioni

<ul>
<li><strong>Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications: </strong> Demonstrates the role of 1-Stearoyl-sn-glycero-3-phosphocholine in preventing oxidative modifications in cellular membranes, pertinent to drug delivery systems and cell signaling studies (Soler-Cantero et al., 2012).</li>
</ul>

Azioni biochim/fisiol

1-Stearoyl-sn-glycero-3-phosphocholine (LPC, Lyso-PC) is used in the development of drug transdermal delivery devices such as liposomes and micelles. It inhibits histone deacetylase 3 (HDAC3) activity and signal transducer and activator of transcription 3 (STAT3) phosphorylation and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells.
1-Stearoyl-sn-glycero-3-phosphocholine (LPC, Lyso-PC) is used in the development of drug transdermal delivery devices such as liposomes and micelles.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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1-O-Palmityl-sn-glycero-3-phosphocholine &#8805;99%, synthetic

Sigma-Aldrich

L5016

1-O-Palmityl-sn-glycero-3-phosphocholine

Sigma-Aldrich

Sigma-Aldrich

L0906

L-α-lisofosfatidilcolina

Lisofosfatidilcolina United States Pharmacopeia (USP) Reference Standard

USP

1372050

Lisofosfatidilcolina

18:0 Lyso PG Avanti Research&#8482; - A Croda Brand

Avanti

858124P

18:0 Lyso PG

L-&#945;-lisofosfatidilcolina European Pharmacopoeia (EP) Reference Standard

Y0001904

L-α-lisofosfatidilcolina

USP

USP

1372061

Lisofosfatidilcolina (soia)

vibrant-m

Y0001952

L-α-lisofosfatidilcolina

L-&#945;-Lysophosphatidylcholine from soybean, &#8805;98.0% (10 mg phospholipid per ml CHCl3, TLC)

Sigma-Aldrich

62963

L-α-Lysophosphatidylcholine

Asako Katsume et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(5), 1084-1092 (2011-03-05)
Reactive oxygen species (ROS) are involved in the initial process of atherosclerosis, whereas it remains to be determined how atherogenic stimulus causes ROS-mediated proinflammatory reactions. Here, we focused on proline-rich tyrosine kinase (PYK2)-mediated ROS generation and examined how atherogenic stimulus
Ji Hoon Jung et al.
Cell biochemistry and biophysics, 67(3), 1379-1389 (2013-06-04)
We here investigated the anticancer mechanism of 1-stearoyl-sn-glycero-3-phosphocholine (LPC), one of the lysophosphatidylcholines, in chronic myelogenous leukemia (CML) K562 cells. LPC significantly showed cytotoxicity at 80 μM and induced apoptosis by sub-G1 accumulation, increase in Annexin V positive and caspase
Michał Flasiński et al.
Journal of colloid and interface science, 348(2), 511-521 (2010-05-25)
The interactions of beta-CD with one component monolayers of cholesterol (chol), 1-stearoyl-sn-glycero-3-phosphocholine (lyso-PC), 1,2-dipalmitpyl-sn-phosphocholine (DPPC), sphingomyelin (SM) and the SM/chol and DPPC/chol mixtures have been investigated by the Langmuir monolayer technique and the synchrotron grazing incidence X-ray diffraction (GIXD). The
Marcus O W Grimm et al.
Journal of chromatography. A, 1218(42), 7713-7722 (2011-08-30)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by extracellular senile plaques mainly consisting of Aβ, a 40-42 amino acid long peptide, and intracellular neurofibrillary tangles, accompanied by an excessive loss of synapses. Recently evidence accumulated that nutrition, especially
Jongwon Shim et al.
International journal of pharmaceutics, 388(1-2), 251-256 (2010-01-12)
We have studied how the transdermal delivery of lidocaine hydrochloride (LHC) is affected by the morphology of lipid carriers, liposomes and micelles, having the same lipid composition of 1-stearoyl-sn-glycero-3-phosphocholine (LPC) and cholesteryl hemisuccinate (CHEMS). In vitro drug permeation study, carried
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