L1378
L-Lactic Dehydrogenase from bovine muscle
Type X, ammonium sulfate suspension, ≥600 units/mg protein
Sinonimo/i:
(S)-Lactate: NAD+ oxidoreductase, L-LDH, LAD, LD, Lactate
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Prodotti consigliati
Origine biologica
bovine muscle
Livello qualitativo
Tipo
Type X
Saggio
3.0—25.0 mg protein/mL (biuret)
Stato
ammonium sulfate suspension
Attività specifica
≥600 units/mg protein
Produttore/marchio commerciale
Sigma-Aldrich
tecniche
activity assay: suitable
Colore
white
pH
7.5
applicazioni
life science and biopharma
Attività estranea
pyruvate kinase ≤0.01%
Temperatura di conservazione
2-8°C
Informazioni sul gene
cow ... LDHA(281274) , LDHB(281275)
Descrizione generale
Research Area: Cell Signaling
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Applicazioni
L-Lactic Dehydrogenase from bovine muscle has been used in lactate assay to assess lactate tissue accumulation.
Azioni biochim/fisiol
Lactate dehydrogenase (LDH) plays a critical role as a checkpoint in gluconeogenesis and DNA metabolism. It plays a vital role in maintaining homeostasis during periods of low oxygen availability. As an oxidoreductase enzyme, lactate dehydrogenase catalyzes the reversible conversion of pyruvate to lactate using NADH. This enzyme is crucial for the anaerobic metabolism of glucose when oxygen is either absent or in short supply. LDH is the sole serum biomarker effective for evaluating metastatic melanomas.
Also catalyzes the oxidation of other L-2-hydroxymonocarboxylic acids.
Definizione di unità
One unit will reduce 1.0 μmole of pyruvate to L-lactate per min at pH 7.5 at 37 °C.
Stato fisico
Crystalline suspension in 2.4 M (NH4)2SO4 solution, pH 6.0
Risultati analitici
Protein determined by biuret.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Vasco Meneghini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6047-6059 (2013-04-05)
Dysregulated hippocampal neurogenesis has been associated with neurodegenerative disorders, including Alzheimer's disease (AD), in which it may potentially represent an auto-reparatory mechanism that could counteract neuronal loss and cognitive impairment. We evaluated hippocampal neurogenesis in TgCRND8 mice and reported that
Sebastian-Jonas Saur et al.
Deutsche medizinische Wochenschrift (1946), 138(16), Seite 1-Seite30 (2013-04-24)
We report on the case of a young women presenting with macrohaematuria, petechiae and strong headaches. Laboratory showed a thrombotic microangiopathy with helmet cells, increased LDH levels (>600 U/l), and thrombocytopenia (<40,000/μl). Due to strong haemolytic activity and headache with
Wei Quan et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 85-91 (2013-04-20)
To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. MI/R injury was induced by the occlusion of left anterior descending coronary artery for
O V Basharina et al.
Radiatsionnaia biologiia, radioecologiia, 52(6), 602-607 (2013-03-23)
The influence of UV-light (240-390 nm) at the dozes of 151 and 755 J/m2 on the intensity of processes of the lipid peroxidation, activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), cytochrome c oxidase and the level of the energy
Bécaye Fall et al.
Malaria journal, 12, 107-107 (2013-03-21)
In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of resistance of P. falciparum to
Articoli
Instructions for working with enzymes supplied as ammonium sulfate suspensions
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.