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Documenti fondamentali

J4252

Sigma-Aldrich

JWH-015

≥98% (HPLC), powder

Sinonimo/i:

(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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About This Item

Formula empirica (notazione di Hill):
C23H21NO
Numero CAS:
Peso molecolare:
327.42
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

Livello qualitativo

Saggio

≥98% (HPLC)

Stato

powder

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

Colore

off-white

Solubilità

DMSO: >20 mg/mL (with heating)

Temperatura di conservazione

−20°C

Stringa SMILE

CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14

InChI

1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3
LJSBBBWQTLXQEN-UHFFFAOYSA-N

Informazioni sul gene

human ... CNR2(1269)
rat ... Cnr1(25248)

Applicazioni

JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.

Azioni biochim/fisiol

JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.

Caratteristiche e vantaggi

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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Certificati d'analisi (COA)

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Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid
XiaoPing G, et al.
Journal of Cell Science, jcs-100925 (2012)
Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
Jinhong Liu et al.
Experimental and therapeutic medicine, 18(6), 4241-4248 (2019-11-30)
Inflammation serves an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Cannabinoid receptor 2 (CB2R) is a receptor predominantly expressed in the immune system. CB2R agonists can be used to treat a wide range of inflammation-related diseases. Pirfenidone
Sumana Ghosh et al.
Frontiers in cellular neuroscience, 12, 271-271 (2018-09-07)
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)

Articoli

Synthetic cannabinoids (e.g. "Spice") are a type of designer drug that provides a cannabis-type high.

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

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