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I6658

Sigma-Aldrich

Isradipine

≥98% (HPLC), solid

Sinonimo/i:

4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester

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About This Item

Formula empirica (notazione di Hill):
C19H21N3O5
Numero CAS:
75695-93-1
Peso molecolare:
371.39
Numero MDL:
MFCD00153820
Codice UNSPSC:
12352200
ID PubChem:
24724517
NACRES:
NA.77

Descrizione

Store under nitrogen

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Colore

yellow

Solubilità

DMSO: >10 mg/mL

Ideatore

Novartis

Temperatura di conservazione

2-8°C

Stringa SMILE

COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C

InChI

1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
HMJIYCCIJYRONP-UHFFFAOYSA-N

Informazioni sul gene

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781)

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Applicazioni

Isradipine has been used to explore neuroprotective activity.

Azioni biochim/fisiol

Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
079K4708V
079K47081
079K4708
038K46182
038K46181

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Petra Geier et al.
American journal of physiology. Cell physiology, 300(4), C937-C949 (2011-01-14)
L-type voltage-gated calcium channels (LTCCs) have long been considered as crucial regulators of neuronal excitability. This role is thought to rely largely on coupling of LTCC-mediated Ca(2+) influx to Ca(2+)-dependent conductances, namely Ca(2+)-dependent K(+) (K(Ca)) channels and nonspecific cation (CAN)
Rodrigo Almeida Simões et al.
Analytical and bioanalytical chemistry, 399(7), 2435-2443 (2011-01-20)
An enantioselective liquid chromatographic method using two-phase hollow fiber liquid-phase microextraction (HF-LPME-HPLC) was developed for the determination of isradipine (ISR) enantiomers and its main metabolite (pyridine derivative of isradipine, PDI) in microsomal fractions isolated from rat liver. The analytes were
C Savio Chan et al.
Movement disorders : official journal of the Movement Disorder Society, 25 Suppl 1, S63-S70 (2010-02-27)
Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. There is no cure or proven strategy for slowing the progression of the disease. Although there are signs of pathology in many brain regions, the core symptoms of PD
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Push-pull osmotic systems have been developed to deliver poorly soluble drugs in a modified-release fashion. The aim of this study was to investigate the influence of the tablet core factors on the drug release kinetics and loadability. The release kinetics
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Disease models & mechanisms, 4(5), 634-648 (2011-05-21)
A growing body of evidence supports the 'calcium hypothesis' of Alzheimer's disease (AD), which postulates that a variety of insults might disrupt the homeostatic regulation of neuronal calcium (Ca(2+)) in the brain, resulting in the progressive symptoms that typify the
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