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I6385

Sigma-Aldrich

Monoclonal Anti-Human IgM (μ-chain specific) antibody produced in mouse

clone MB-11, ascites fluid

Sinonimo/i:

Monoclonal Anti-Human IgM (μ-chain specific)-Alkaline Phosphatase, Anti Human IgM Antibody - Monoclonal Anti-Human IgM (μ-chain specific) antibody produced in mouse, Anti Human Igm Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

mouse

Livello qualitativo

300

Coniugato

unconjugated

Forma dell’anticorpo

ascites fluid

Tipo di anticorpo

secondary antibodies

Clone

MB-11, monoclonal

contiene

15 mM sodium azide

tecniche

indirect ELISA: 1:5,000

Isotipo

IgG2b

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

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Descrizione generale

Human serum-derived IgM may be used as a reference antigen, standard, blocking agent, or coating protein in a variety of immunoassays including ELISA, dot immunobinding, Western immunoblotting, immunodiffusion, and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solid phase immunoadsorbents.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
IgM is a highly conserved antibody in vertebrates and is expressed early during immune response. It exists as a pentamer and is secreted by peritoneal B cells.
Mouse monoclonal clone MB-11 anti-Human IgM (μ-chain specific) antibody is specific for the μ-chain of human IgM as determined by an ELISA. It does not bind human IgG, IgA, or light chains.

Applicazioni

Mouse monoclonal clone MB-11 anti-Human IgM (μ-chain specific) antibody may be used to identify and quantitate the level of human IgM in vitro and in human serum or other biological fluids by immunochemical or immunohistological techniques. Elisa assays were performed using alkaline phosphatase conjugated anti-human IgM to detect IgMs in phage supernatants and human sera at 1:1000 dilution.

Azioni biochim/fisiol

IgM plays a key role in the engulfing of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Emerging functions of natural IgM and its Fc receptor FCMR in immune homeostasis.
Wang H, et al.
Frontiers in Immunology, 7(11), 99-99 (2016)
Anna Babakhanyan et al.
PloS one, 9(2), e88173-e88173 (2014-02-08)
In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding site of VAR2CSA is present in the ID1-ID2a region. This study sought to determine if pregnant Cameroonian
Andrew Bentall et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(12), 1235-1243 (2014-07-06)
Terminal complement blockade has been shown to decrease the incidence of early acute antibody-mediated rejection (eAMR) in the first month after positive cross-match kidney transplant recipients, yet some patients still develop eAMR. The current study investigated possible mechanisms of eAMR
D Martins de Medeiros et al.
Lupus, 23(13), 1412-1416 (2014-06-26)
The objective of this report is to conduct short- and long-term evaluation of a large panel of antiphospholipid (aPL) autoantibodies following pandemic influenza A/H1N1 non-adjuvant vaccine in primary antiphospholipid syndrome (PAPS) patients and healthy controls. Forty-five PAPS and 33 healthy
Andi Krumbholz et al.
Medical microbiology and immunology, 203(4), 273-282 (2014-04-20)
An increase in acute autochthonous hepatitis E virus (HEV) infections has been recorded in Germany. These are suspected to be zoonotically transmitted from wild boar, deer and domestic pig. The latter may represent a major reservoir for HEV. In this
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