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B1265

Sigma-Aldrich

Anti-Human IgM (μ-chain specific)−Biotin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

goat

Livello qualitativo

Coniugato

biotin conjugate

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

secondary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

tecniche

direct ELISA: 1:20,000

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Descrizione generale

Human IgMs are the initial immunoglobulin isotypes that appear in blood in response to the first exposure to external antigens. IgMs have been implicated in CNS myelin repair and increased secretory IgM levels have been linked to rhino-conjunctivitis . Anti-Human IgM (μ-chain specific)-Biotin antibody is specific for human IgM and does not bind other human immunoglobulins.
IgM antibody is produced by B cells and plays a pivotal role in primary defence mechanism. The main function is to recognise and eliminate foreign invaders like bacteria and viruses, cellular waste as well as precancerous and cancerous lesions. Anti-human IgM (μ-chain specific) −biotin antibody can be used in micro ELISA to determine IgD isotype antibody to phosphorylcholine (PC) . Goat anti-human IgM antibodies react specifically with human IgM but not with other human immunoglobulins.

Immunogeno

Purified human IgM
Purified human IgM.

Applicazioni

Anti-Human IgM (μ-chain specific)-Biotin antibody is suitable for use in ELISA (1:2000) .

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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S D Litwin et al.
European journal of immunology, 17(4), 483-489 (1987-04-01)
As part of a broader analysis into the function of IgD, and especially into the role of human IgD-secreting cells, fresh human tonsil lymphocyte cultures were analyzed. The goals were to define the origins of "externalized" supernatant IgD and to
A Ripamonti et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(48), 12797-12802 (2017-11-15)
Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of TFH cells are controlled by the master gene BCL6, but it is largely unclear how
Miguel A Trujillo et al.
DNA and cell biology, 22(8), 513-523 (2003-10-21)
We examined the role of BCR cell membrane redistribution in anti-IgM-induced apoptosis in three human B cell lines, RA#1, 2G6, and MC116, that differ in their relative levels of sIgM expression. The apoptotic response was found to be dependent on
Marta Vidal et al.
Journal of immunological methods, 455, 41-54 (2018-02-06)
Quantitative suspension arrays are powerful immunoassays to measure antibodies against multiple antigens in large numbers of samples in a short time and using few microliters. To identify antigen targets of immunity for vaccine development against complex microbes like Plasmodium falciparum
Bengt Rönnberg et al.
Medical microbiology and immunology, 206(5), 383-401 (2017-08-31)
The recent spread of Zika virus (ZIKV) in the Americas and Asia necessitates an increased preparedness for improved maternal and perinatal health and blood safety. However, serological cross-reactions, especially to Dengue virus (DENV), complicate ZIKV antibody serodiagnosis. A novel "pan-Flavi"

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