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H6291

Sigma-Aldrich

IL-1β human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Sinonimo/i:

IL-1β, Lymphocyte activating factor

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About This Item

Numero MDL:
MFCD00131399
Codice UNSPSC:
12352202
NACRES:
NA.77

product name

Interleukin-1β human, IL-1β, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture, endotoxin tested

Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in HEK 293 cells

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

≤0.05 ng/mL EC50

Qualità

endotoxin tested

PM

dimer 18-25 kDa (glycosylated)

Confezionamento

pkg of 10 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<1 EU/μg

N° accesso UniProt

P01584

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IL1B(3553)

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Azioni biochim/fisiol

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses. Other synonyms for IL-1 include: endogenous pyrogen (EP), mitogenic protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFM), B Cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF) The two closely related agents Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) share 62% homology in amino acid sequence and elicit nearly identical biological responses. IL-1α and IL-1β are both approximately 17 kDa with some heterogeneity in the amount of glycosylation.

Stato fisico

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota sulla preparazione

HumanKine Recombinant Human IL-1β, expressed in human HEK 293 cells, is a glycosylated monomer with a molecular mass of 18-25 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Risultati analitici

The activity is determined by the dose-dependent stimulation of the proliferation of mouse D10S cells.

Note legali

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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