F8512

Anti-Fibrinogen antibody produced in goat

whole antiserum

• Sinonimo/i: Anti-Fib2
• Numero MDL: MFCD00162408
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: goat
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: whole antiserum
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• contiene: 15 mM sodium azide
• Reattività contro le specie: human
• tecniche: indirect ELISA: 1:10,000; quantitative precipitin assay: 2.0 mg/mL
• N° accesso UniProt: P02671
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... FGA(2243) , FGB(2244) , FGG(2266)

Descrizione

Descrizione generale

Fibrinogen is a thrombin-coagulable soluble plasma 340 kDa glycoprotein, composed of paired sets of three subunits i.e. α, β, γ. It plays a crucial role in protecting the vascular network against the loss of blood after tissue injury. Among three subunits, β and γ subunits contain one N-glycosylation site, which is occupied by a biantennary N-glycan. It contains three pairs of disulfide-bonded chains called α, β and γ which further folded into four structural domains: the D, E, connector, and the COOH-terminal region of the Aα chain.

The fibrinogen gene cluster consists of fibrinogen α, β and γ chains. It is localized on human chromosome locus 4q31.3−4q32.1.

Specificità

The antiserum has been determined to be immunospecific for fibrinogen by immunoelectrophoresis versus human plasma and fibrinogen.

Immunogeno

human fibrinogen

Applicazioni

Anti-Fibrinogen antibody is suitable for immunostaining in fibrin deposition analysis of mouse livers and capturing antibodies in the sandwich ELISA. It is also suitable for indirect ELISA at a dilution of 1:10,000 and quantitative precipitin assay at 2.0mg/mL concentration.

Anti-Fibrinogen antibody produced in goat has been used in:

• western blotting detection in human colon adenocarcinoma cell line
• detecting fibrinogen in plasma
• immunoassay of human platelet free plasma (PFP)

Azioni biochim/fisiol

Plasmin attacks the Aα chain COOH domain to produce the heterogeneous fragment X. Multiple round of degradation ended with terminal digestion products−fragments D and E which represent the major globular domains in fibrinogen. Mutations in this gene lead to several disorders, including hypofibrinogenemia and afibrinogenemia.

Nota sulla preparazione

treated to remove lipoproteins

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable