D9035

Diazoxide

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

• Sinonimo/i: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Formula empirica (notazione di Hill): C₈H₇ClN₂O₂S
• Numero CAS: 364-98-7
• Peso molecolare: 230.67
• Numero CE: 206-668-1
• Numero MDL: MFCD00078578
• Codice UNSPSC: 12352119
• ID PubChem: 24277831
• NACRES: NA.77

Proprietà

• Nome del prodotto: Diazoxide,
• Stato: powder
• Solubilità: 0.1 M NaOH: soluble; H₂O: insoluble; methanol: soluble
• Ideatore: Schering Plough
• Stringa SMILE: CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
• InChI: 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11); GDLBFKVLRPITMI-UHFFFAOYSA-N
• Informazioni sul gene: human ... KCNA1(3736) , KCNJ11(3767) , KCNJ8(3764) , KCNMA1(3778) ; mouse ... Kcnj1(56379) , Kcnj11(16514) ; rat ... Gria1(50592) , Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj8(25472)

Descrizione

Descrizione generale

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell K_ATP channel opener. Diazoxide prevents the secretion of insulin.

Applicazioni

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K⁺-induced exocytosis.

Azioni biochim/fisiol

Selective ATP-sensitive K⁺ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319,H335
• Consigli di prudenza: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves