D6134
2-deossi-D-glucosio
≥99% (GC), crystalline
Sinonimo/i:
2-deossi-D-arabinoesoso
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About This Item
Formula empirica (notazione di Hill):
C6H12O5
Numero CAS:
Peso molecolare:
164.16
Beilstein:
1723331
Numero CE:
Numero MDL:
Codice UNSPSC:
12352201
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Origine biologica
synthetic (organic)
Saggio
≥99% (GC)
Stato
crystalline
tecniche
gas chromatography (GC): suitable
Colore
white
Punto di fusione
146-147 °C (lit.)
Solubilità
H2O: soluble 330 mg/mL, clear, colorless
Temperatura di conservazione
2-8°C
Stringa SMILE
OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI
1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
VRYALKFFQXWPIH-PBXRRBTRSA-N
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Applicazioni
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Azioni biochim/fisiol
Il 2-deossi-D-glucosio (2-deossiglucosio) è un analogo del glucosio che inibisce la glicolisi agendo sull′esochinasi, lo stadio lento della glicolisi. È fosforilato dall′esochinasi a 2-DG-P che non può essere ulteriormente metabolizzato dalla fosfoglucosio isomerasi. Ciò comporta l′accumulo di 2-DG-P nella cellula e la deplezione dell′ATP cellulare. In vitro, il 2-deossiglucosio ha dimostrato di indurre l′autofagia, aumentare la produzione di ROS e attivare la AMPK.
Nota sulla preparazione
A further purification of the Grade II material by recrystallization.
Altre note
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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