D5412

2′-Deoxyuridine

≥98.5%

• Sinonimo/i: 1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside
• Formula empirica (notazione di Hill): C₉H₁₂N₂O₅
• Numero CAS: 951-78-0
• Peso molecolare: 228.20
• Beilstein: 24433
• Numero CE: 213-455-7
• Numero MDL: MFCD00006527
• Codice UNSPSC: 41106305
• ID PubChem: 24893831
• NACRES: NA.51

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98.5%
• Forma fisica: powder
• Impurezze: Thymidine, free
• Solubilità: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Stringa SMILE: OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1; MXHRCPNRJAMMIM-SHYZEUOFSA-N
• Informazioni sul gene: mouse ... Slc29a1(63959)

Descrizione

Applicazioni

2′-Deoxyuridine has been used as a:

• precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays
• nucleoside supplement for cell cycle synchronization and DNA replication inhibition
• mitotic inhibitor in culture media to minimize the proliferation of glial cells

Azioni biochim/fisiol

2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)