C4116

Cyclopamine hydrate

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

• Sinonimo/i: 11-deoxojervine hydrate
• Formula empirica (notazione di Hill): C₂₇H₄₁NO₂ · xH₂O
• Numero CAS: 1217465-07-0
• Peso molecolare: 411.62 (anhydrous basis)
• Codice UNSPSC: 12352116
• ID PubChem: 24724439
• NACRES: NA.77

Proprietà

• product name: Cyclopamine hydrate, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white
• Solubilità: DMSO: soluble ≥5 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
• InChI: 1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1; KDAGJRDPNXDDSB-HBYCUIHISA-N
• Informazioni sul gene: human ... EBP(10682)

Descrizione

Descrizione generale

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Applicazioni

Cyclopamine hydrate has been used:

• as a sonic hedgehog (Shh) inhibitor in various experiments
• to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
• to study its influence on ocular vessel patterning

Azioni biochim/fisiol

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)