C0737

Cilostazol

≥98% (HPLC), powder

• Sinonimo/i: 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal
• Formula empirica (notazione di Hill): C₂₀H₂₇N₅O₂
• Numero CAS: 73963-72-1
• Peso molecolare: 369.46
• Numero MDL: MFCD00866780
• Codice UNSPSC: 41106305
• ID PubChem: 24278291
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: off-white
• Solubilità: DMSO: 10 mg/mL, clear
• Ideatore: Otsuka Pharma
• Stringa SMILE: O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1
• InChI: 1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26); RRGUKTPIGVIEKM-UHFFFAOYSA-N
• Informazioni sul gene: human ... PDE3A(5139) , PDE3B(5140)

Descrizione

Descrizione generale

Cilostazol prevents platelet aggregation and has vasodilatory properties. It is used to treat chronic arterial disease and intermittent claudication. Cilostazol has antiproliferative effects and improves the properties of prostacyclin. It regulates cell proliferation, stimulates cyclic adenosine monophosphate (cAMP) level and induces cyclic AMP-dependent protein kinase.

Applicazioni

Cilostazol has been used:

• to reduce Madin–Darby cell line (MDCK) proliferation through c-Myc down-regulation
• in the in vitro assessment of toxin delivery in T84 intestinal epithelial cells
• to induce adenosine triphosphate (ATP) release in white adipocytes

Azioni biochim/fisiol

Phosphodiesterase III (PDE3) inhibitor

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Otsuka Pharma. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H361d
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)