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A7793

Sigma-Aldrich

5-Aminolevulinic acid hydrochloride

BioReagent, suitable for cell culture, powder, ≥98%

Sinonimo/i:

δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA

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About This Item

Formula condensata:
NH2CH2C(O)CH2CH2COOH · HCl
Numero CAS:
5451-09-2
Peso molecolare:
167.59
Beilstein:
3690651
Numero CE:
226-679-5
Numero MDL:
MFCD00012869
Codice UNSPSC:
12352209
ID PubChem:
24891281
NACRES:
NA.75

Nome Commerciale

BioReagent

Livello qualitativo

200

Saggio

≥98%

Forma fisica

powder

tecniche

cell culture | mammalian: suitable

Solubilità

H2O: 50 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].NCC(=O)CCC(O)=O

InChI

1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
ZLHFONARZHCSET-UHFFFAOYSA-N

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Applicazioni

5-Aminolevulinic acid formed from glycine and succinyl CoA by ALA synthase is the first compound in prophyrin biosynthesis pathway. 5-Aminolevulinic acid is used in photodynamic therapy. This compound may be used to study the effects of photodynamic therapy in vitro.

Azioni biochim/fisiol

Intermediate in heme biosynthesis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Firas Şueki et al.
Photodiagnosis and photodynamic therapy, 27, 95-99 (2019-05-18)
Photodynamic Therapy (PDT) is a promising antitumor and anti-bacterial treatment method for its high selectivity, non-invasiveness, and minimal side effects. However, cellular mechanisms may lead to PDT resistance and thus effect efficacy. The aim of this study is to test
J D Bastian et al.
Osteoarthritis and cartilage, 17(4), 539-546 (2008-10-08)
Outcome in osteochondral allografting is limited by the immunological incompatibility of the grafted tissue. Based on a resistance of chondrocytes to photodynamic therapy in cell culture it is proposed that 5-aminolevulinic acid-based photodynamic therapy (5-ALA-PDT) might be used to inactivate
Pablo A Valdés et al.
Journal of neurosurgery, 123(3), 771-780 (2015-07-04)
Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival. Despite the benefits of complete
Michael Jermyn et al.
Biomedical optics express, 6(12), 5063-5074 (2015-12-30)
In glioma surgery, Protoporphyrin IX (PpIX) fluorescence may identify residual tumor that could be resected while minimizing damage to normal brain. We demonstrate that improved sensitivity for wide-field spectroscopic fluorescence imaging is achieved with minimal disruption to the neurosurgical workflow
J P Golding et al.
Veterinary and comparative oncology, 15(4), 1543-1552 (2017-01-28)
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the
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