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Key Documents

08339

Sigma-Aldrich

5-Aminolevulinic acid hydrochloride

≥97.0% (AT)

Sinonimo/i:

δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA

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About This Item

Formula condensata:
NH2CH2C(O)CH2CH2COOH · HCl
Numero CAS:
Peso molecolare:
167.59
Beilstein:
3690651
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.26

Livello qualitativo

Saggio

≥97.0% (AT)

Forma fisica

powder or crystals

Impurezze

≤2% water

Colore

white to faint yellow

Punto di fusione

~150 °C (dec.)

applicazioni

peptide synthesis

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl[H].NCC(=O)CCC(O)=O

InChI

1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
ZLHFONARZHCSET-UHFFFAOYSA-N

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Applicazioni

5-Aminolevulinic acid hydrochloride has been used as a supplement for culturing Escherichia coli cells for heme biosynthesis.

Azioni biochim/fisiol

5-Aminolevulinic acid (5-ALA) may interact with several transporters such as glutamate, γ-aminobutyric acid (GABA), di-, tri-peptides, and organic transporters in the blood-brain barrier. It may also act as a precursor for the synthesis of porphyrins in chlorophyll and hemes. 5-ALA exhibits plant growth regulator activities.
Intermediate in heme biosynthesis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Hidetoshi Takahashi et al.
The Journal of dermatology, 41(8), 729-731 (2014-08-08)
Photodynamic therapy (PDT) is useful for superficial skin tumors such as actinic keratosis and Bowen disease. Although PDT is non-surgical and easily-performed treatment modality, irradiation apparatus is large and expensive. Using 7, 12-dimethylbenz[a]anthracene (DMBA) and 12-ο-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin papilloma
N Neittaanmäki-Perttu et al.
The British journal of dermatology, 171(5), 1172-1180 (2014-08-12)
Daylight-mediated photodynamic therapy (DL-PDT) using methyl-5-aminolaevulinate (MAL) is effective for thin, grade I, actinic keratoses (AK). There are no published studies of other photosensitizers used in DL-PDT. To compare the efficacy and adverse effects of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA)
Giovanni Pagano et al.
International journal of molecular sciences, 15(11), 20169-20208 (2014-11-08)
An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed "mitochondrial nutrients" (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its derivatives) have been tested in
E Yakes Jimenez et al.
Prostaglandins, leukotrienes, and essential fatty acids, 95, 71-78 (2015-01-21)
Adequate long-chain polyunsaturated fatty acid (LCPUFA) intake is critical during the fetal and infant periods. We quantified fatty acid content of breast milk (n=718) and plasma from six month old infants (n=412) in southern Malawi, and in usipa (n=3), a
Zhimin Yang et al.
PloS one, 9(12), e116283-e116283 (2015-01-01)
The objectives of this study were to determine whether foliar application of a chlorophyll precursor, 5-aminolevulinic acid (ALA), could mitigate salinity stress damages in perennial grass species by regulating photosynthetic activities, ion content, antioxidant metabolism, or metabolite accumulation. A salinity-sensitive

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