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A7219

Sigma-Aldrich

L-Aspartic acid

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sinonimo/i:

(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid

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About This Item

Formula condensata:
HO2CCH2CH(NH2)CO2H
Numero CAS:
56-84-8
Peso molecolare:
133.10
Beilstein:
1723530
Numero CE:
200-291-6
Numero MDL:
MFCD00002616
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
24891191
NACRES:
NA.75

Origine biologica

non-animal source

Livello qualitativo

300

agenzia

meets EP testing specifications
meets USP testing specifications

Saggio

98.5-101.0%

Stato

powder

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

Colore

white to off-white

Punto di fusione

>300 °C (dec.) (lit.)

Solubilità

1 M HCl: 100 mg/mL

Stringa SMILE

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
CKLJMWTZIZZHCS-REOHCLBHSA-N

Informazioni sul gene

human ... CA1(759) , CA2(760)
rat ... Grin2a(24409)

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Descrizione generale

Aspartic acid(ASP)/aspartate, a non-essential amino acid, is naturally produced by mammals. ASP is one of the 20 building-block amino acids of proteins and has a one letter code, D. L-Aspartic acid can be manufactured industrially by an enzymatic process using the aspartase enzyme.

Applicazioni

L-Aspartic acid has been used:
  • as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats
  • as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)
  • as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines

Azioni biochim/fisiol

Principal neurotransmitter for fast synaptic excitation.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000297395
0000297395
SLCK6694
SLCK5576
SLCH2841

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Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].
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