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A6376

Sigma-Aldrich

N-Acetyl-L-tryptophan

≥99% (TLC), suitable for ligand binding assays

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About This Item

Formula empirica (notazione di Hill):
C13H14N2O3
Numero CAS:
1218-34-4
Peso molecolare:
246.26
Numero CE:
214-935-9
Numero MDL:
MFCD00065976
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
24891081
NACRES:
NA.26

product name

N-Acetyl-L-tryptophan,

Saggio

≥99% (TLC)

Livello qualitativo

200

Forma fisica

powder

tecniche

ligand binding assay: suitable

Colore

white to off-white

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI

1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
DZTHIGRZJZPRDV-LBPRGKRZSA-N

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Categorie correlate

Azioni biochim/fisiol

N-Acetyl-L-tryptophan (NAT, Ac-Trp-OH) is used a substance P NK1 tachykinin receptor antagonist. N-Acetyl-L-tryptophan is also used as a competitive inhibitor to identify, differentiate and characterized tryptophanase(s).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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James J Donkin et al.
Journal of neurotrauma, 28(2), 217-224 (2010-12-24)
Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an
New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.
Scherzer R, Gdalevsky GY, et al.
Journal of Enzyme Inhibition, 24, 350-355 (2009)
Kate M Lewis et al.
Anti-cancer drugs, 24(4), 344-354 (2013-02-15)
Emend, an NK1 antagonist, and dexamethasone are used to treat complications associated with metastatic brain tumours and their treatment. It has been suggested that these agents exert anticancer effects apart from their current use. The effects of the NK1 antagonists
Toshinori Suzuki et al.
Free radical biology & medicine, 37(5), 671-681 (2004-08-04)
Proteins are targets of reactive nitrogen species such as peroxynitrite and nitrogen dioxide. Among the various amino acids in proteins, tryptophan residues are especially susceptible to attack by reactive nitrogen species. We carried out experiments on the reactions of peroxynitrite
Renée J Turner et al.
Brain research, 1393, 84-90 (2011-04-07)
Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role
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