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Key Documents

PHR1173

Supelco

N-Acetyl-L-tyrosine

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Formula condensata:
4-(HO)C6H4CH2CH(NHCOCH3)CO2H
Numero CAS:
Peso molecolare:
223.23
Beilstein:
2697172
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to USP 1010106

Famiglia di API

acetyltyrosine

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

149-152 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1
CAHKINHBCWCHCF-JTQLQIEISA-N

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Descrizione generale

N-Acetyl-L-tyrosine is an acetyl derivative of the amino acid, L-tyrosine. It is freely soluble in water compared to L-tyrosine and is commonly used as a parenteral nutrition supplement.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

N-Acetyl-L-tyrosine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by titrimetry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA6108 in the slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti correlati

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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Sigma-Aldrich

T8566

L-tirosina

Sigma-Aldrich

Sigma-Aldrich

SRE0027

Eparina

N-Acetyltyrosine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 38(3)(5), 4702-4702 (2018)
N-Acetyltyrosine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 1641-1642 (2017)
L John Hoffer et al.
JPEN. Journal of parenteral and enteral nutrition, 27(6), 419-422 (2003-11-19)
N-acetyl-L-tyrosine (NAT) is commonly used in place of tyrosine in parenteral nutrition, but human studies carried out to date indicate considerable amounts of it are excreted unchanged in the urine. NAT retention has not been well studied in parenterally fed
A R Butler et al.
Nitric oxide : biology and chemistry, 4(5), 472-482 (2000-10-06)
By the observation of chemically induced dynamic nuclear polarization in (15)N NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even under acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main
N-acetyl tyrosyluria caused by parenteral or enteral administration of N-acetyl-L-tyrosine: differentiation from hereditary and acquired tyrosinemias.
Stanley H Korman et al.
Journal of pediatric gastroenterology and nutrition, 39(1), 95-100 (2004-06-10)

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