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Key Documents

Altri documenti

85590

Sigma-Aldrich

Spermine

≥99.0% (GC)

Sinonimo/i:

N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine

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About This Item

Formula condensata:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Numero CAS:
71-44-3
Peso molecolare:
202.34
Beilstein:
1750791
Numero CE:
200-754-2
Numero MDL:
MFCD00008215
Codice UNSPSC:
12352116
ID PubChem:
329769392
NACRES:
NA.25

Origine biologica

microbial
synthetic

Livello qualitativo

200

Saggio

≥99.0% (GC)

Forma fisica

crystalline (chunks)

Impurezze

≤0.5% spermidine

P. eboll.

150 °C/5 mmHg (lit.)

Punto di fusione

28-30 (lit.)

Solubilità

water: 0.05 g/mL, clear, colorless

Anioni in tracce

carbonate (CO32-): ≤5000 mg/kg

Temperatura di conservazione

2-8°C

Stringa SMILE

[H]N(CCCN)CCCCN([H])CCCN

InChI

1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
PFNFFQXMRSDOHW-UHFFFAOYSA-N

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Applicazioni

Spermine, a polycationic biogenic polyamine derived from spermidine, may be used in a wide variety of biological applications as a supplement or regulatory agent.Used as co-matrix with DHB for MALDI-MS of sialylated glycans in negative ion mode.

Azioni biochim/fisiol

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1B

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Nicole K L Lee et al.
Journal of cellular physiology, 226(6), 1453-1460 (2011-03-18)
The naturally occurring polyamines, spermidine, spermine, and their precursor putrescine, play indispensible roles in both prokaryotic and eukaryotic cells, from basic DNA synthesis to regulation of cell proliferation and differentiation. The rate-limiting polyamine biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine
Y Mechref et al.
Journal of the American Society for Mass Spectrometry, 9(12), 1293-1302 (1998-12-03)
Negative-ion matrix-assisted laser desorption/ionization mass spectra of sialyated glycoconjugates were acquired employing 2,5-dihydroxybenzoic acid (DHB) in conjunction with spermine as a co-matrix. The addition of spermine to DHB permitted an improved crystal formation as well as a higher analyte solubility.
Lydia P P Liew et al.
Bioorganic & medicinal chemistry letters, 23(2), 452-454 (2012-12-26)
Screening of synthesized and isolated marine natural products for in vitro activity against four parasitic protozoa has identified the ascidian metabolite 1,14-sperminedihomovanillamide (orthidine F, 1) as being a non-toxic, moderate growth inhibitor of Plasmodium falciparum (IC(50) 0.89 μM). Preliminary structure-activity
Wendy Wai Yeng Yeo et al.
Journal of nanoscience and nanotechnology, 14(5), 3328-3336 (2014-04-17)
A nano-sized polymer, dextran-spermine (D-SPM), was shown to have the capacity to deliver gene to the lung of mouse via intranasal route. In this study, assessments on the safety profile of D-SPM were performed to complement the gene expression results.
Brian R Lee et al.
Nature neuroscience, 16(11), 1644-1651 (2013-10-01)
In rat models of drug relapse and craving, cue-induced cocaine seeking progressively increases after withdrawal from the drug. This 'incubation of cocaine craving' is partially mediated by time-dependent adaptations at glutamatergic synapses in nucleus accumbens (NAc). However, the circuit-level adaptations
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Articoli

Methods and matrices for mass spectrometry of glycans

Mass Spectrometry of Glycans, method comparison and products

Protocolli

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

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