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17946

Sigma-Aldrich

1α-Hydroxyvitamin D3

≥97.0% (HPLC)

Sinonimo/i:

1α-Hydroxycholecalciferol, Alfacalcidol

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About This Item

Formula empirica (notazione di Hill):
C27H44O2
Numero CAS:
41294-56-8
Peso molecolare:
400.64
Numero CE:
255-297-1
Numero MDL:
MFCD00868328
Codice UNSPSC:
12352205
ID PubChem:
57647693
NACRES:
NA.79

Origine biologica

synthetic

Livello qualitativo

200

Saggio

≥97.0% (HPLC)

Stato

powder or crystals

Colore

white to off-white

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
OFHCOWSQAMBJIW-AVJTYSNKSA-N

Informazioni sul gene

human ... VDR(7421)

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Descrizione generale

1α-Hydroxyvitamin D3, also known as alfacalcidol, is a synthetic vitamin D3 analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Azioni biochim/fisiol

1α-Hydroxyvitamin D3 facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.
Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300

Consigli di prudenza

P301 + P330 + P331 + P310

Classi di pericolo

Acute Tox. 1 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCD7545
BCCB0829
BCBV2694
BCBR6153V
BCBH4146V

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1α,25-Dihydroxyvitamin D3 solution 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

H-089

1α,25-Dihydroxyvitamin D3 solution

7α-Hydroxy-4-cholesten-3-one ≥95.0% (HPLC)

Supelco

52853

7α-Hydroxy-4-cholesten-3-one

Calcitriol solution United States Pharmacopeia (USP) Reference Standard

USP

1086312

Calcitriol solution

25-Hydroxyvitamin D3 solution 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

H-083

25-Hydroxyvitamin D3 solution

Colecalciferolo ≥98% (HPLC)

Sigma-Aldrich

C9756

Colecalciferolo

Colecalciferolo (D3) analytical standard

Supelco

47763

Colecalciferolo (D3)

Carboxymethylcellulose sodium meets USP testing specifications, Medium viscosity

Sigma-Aldrich

C9481

Carboxymethylcellulose sodium

The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis
Shiraishi A, et al.
Calcified Tissue International, 65(4), 311-316 (1999)
Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen
Shiraishi A, et al.
Journal of Bone and Mineral Research, 15(4), 770-779 (2000)
Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis
Osteoporosis (2013)
Hajime Orimo et al.
Current medical research and opinion, 27(6), 1273-1284 (2011-05-11)
The authors conducted a randomized controlled trial to clarify the efficacy and safety of alendronate plus alfacalcidol versus alendronate alone in a clinical setting. Eligible patients were postmenopausal women with severe osteoporosis who were aged 70 years or older and
Chemopreventive effect of a vitamin D3 analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis
Kikuchi H, et al.
Anti-Cancer Drugs, 18(10), 1183-1187 (2007)
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