42579
4-Phenyl-1,2,4-triazoline-3,5-dione
for HPLC derivatization, LiChropur™, ≥98.0% (CHN)
Sinonimo/i:
Cookson reagent, 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, PTAD
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About This Item
Formula empirica (notazione di Hill):
C8H5N3O2
Numero CAS:
Peso molecolare:
175.14
Beilstein:
141548
Numero CE:
Numero MDL:
Codice UNSPSC:
41116105
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Grado
for HPLC derivatization
Livello qualitativo
Saggio
≥98.0% (CHN)
Qualità
LiChropur™
tecniche
HPLC: suitable
Punto di fusione
165-170 °C (dec.) (lit.)
Temperatura di conservazione
2-8°C
Stringa SMILE
O=C1N=NC(=O)N1c2ccccc2
InChI
1S/C8H5N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H
ISULLEUFOQSBGY-UHFFFAOYSA-N
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Descrizione generale
4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D3 (VD3)-related compounds.
Applicazioni
4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.
Note legali
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Chromatographic separation of PTAD-derivatized 25-hydroxyvitamin D3 and its C-3 epimer from human serum and murine skin
Teegarden DM, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 991(1), 118-121 (2015)
Grant A Abernethy
Analytical and bioanalytical chemistry, 403(5), 1433-1440 (2012-03-24)
A method for analysing vitamin D(3) (VD3, cholecalciferol) has been established and validated. This method is rapid and cost effective and is intended for use in quality control in the manufacture of fortified infant formulae and milk powders. Milk or
A S Weiskopf et al.
Journal of mass spectrometry : JMS, 36(1), 71-78 (2001-02-17)
The structural specificity of vitamin D derivatization by PTAD (4-phenyl-1,2,4-triazoline-3,5-dione) was probed using synthetic analogues and ion trap mass spectrometry. EB 1089, a vitamin D(3) analogue which contains a second site for Diels--Alder cycloaddition on its side-chain, allowed the examination
Jiri Adamec et al.
Journal of separation science, 34(1), 11-20 (2010-12-21)
Simultaneous and accurate measurement of vitamin D and 25-hydroxyvitamin D in biological samples is a barrier limiting our ability to define "optimal" vitamin D status. Thus, our goal was to optimize conditions and evaluate an LC-MS method for simultaneous detection
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