52853

7α-Hydroxy-4-cholesten-3-one

≥95.0% (HPLC)

• Sinonimo/i: 7α-Hydroxycholest-4-en-3-one
• Formula empirica (notazione di Hill): C₂₇H₄₄O₂
• Numero CAS: 3862-25-7
• Peso molecolare: 400.64
• Numero MDL: MFCD00870345
• Codice UNSPSC: 41116107
• ID PubChem: 329757894
• NACRES: NA.24

Proprietà

• Grado: analytical standard
• Livello qualitativo: 100
• Saggio: ≥95.0% (HPLC)
• applicazioni: clinical testing
• Formato: neat
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1
• InChI: 1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1; IOIZWEJGGCZDOL-RQDYSCIWSA-N

Descrizione

Descrizione generale

7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

Applicazioni

C4 may be used as a reference standard for the determination of C4 in:

• Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI) as well as LC-MS.
• Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection.
• Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.

Azioni biochim/fisiol

7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable