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17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Sinonimo/i:

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

Formula condensata:
CH3O(CH2CH2O)nCOCH2CH2COOH
Numero CAS:
31961-02-1
Numero MDL:
MFCD00284260
Codice UNSPSC:
51171641
NACRES:
NA.26

Stato

powder

Livello qualitativo

100

PM

Mr ~2100

Punto di fusione

50-53 °C

Estremità Ω

carboxylic acid

Estremità α

methoxy

Temperatura di conservazione

−20°C

Applicazioni

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Azioni biochim/fisiol

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Slide 1 of 5

1 of 5

mPEG10K-Succinimidyl Carboxymethyl Ester average Mn 10,000

Sigma-Aldrich

JKA3016

mPEG10K-Succinimidyl Carboxymethyl Ester

4-Azidobenzoic acid solution ~0.2 M in tert-butyl methyl ether, ≥95.0% (HPLC)

Sigma-Aldrich

778877

4-Azidobenzoic acid solution

Poly(ethylene glycol) methyl ether average Mn ~2,000

Sigma-Aldrich

202509

Poly(ethylene glycol) methyl ether

Poli(etilenglicole) 2000, for synthesis

Sigma-Aldrich

8.21037

Poli(etilenglicole)

DCC 99%

Sigma-Aldrich

D80002

DCC

Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [(3)H]-hypoxanthine in the nucleic acid of parasites. Stearylamine in liposomes significantly inhibits the growth of
Ayman El-Sayed et al.
Journal of pharmaceutical sciences, 101(2), 879-882 (2011-11-17)
We previously reported on a stearylated INF7 peptide (str-INF7), which enhances the endosomal escape of an octaarginine (R8)-modified liposomal particle encapsulating plasmid DNA (pDNA) in a fusion-independent manner. This study examined whether this peptide derivative enhanced the endosomal escape and
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
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