16758

Poli(etilen glicol)-a blocchi-poli(propilen glicol)-a blocchi-poli(etilen glicol)

purified, non-ionic

• Sinonimo/i: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
• Numero CAS: 9003-11-6
• Numero MDL: MFCD00082049
• Codice UNSPSC: 12352104
• NACRES: NA.25

Proprietà

• Livello qualitativo: 100
• Stato: powder
• Qualità: purified
• Impurezze: ≤1.0% water
• pH: 5.0-7.5
• Solubilità: soluble, clear, colorless
• Cationi in tracce: Al: ≤5 mg/kg; As: ≤0.05 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤1000 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• Assorbanza UV: λ: 260 nm A_max: ≤0.3; λ: 280 nm A_max: ≤0..2
• Compatibilità: no residue for filter test
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2; RVGRUAULSDPKGF-UHFFFAOYSA-N

Descrizione

Descrizione generale

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Applicazioni

Poloxamer 407 has been used:

• as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
• for VLDL secretion assay in mice
• to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Azioni biochim/fisiol

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)