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Y0001373

Nicergoline

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester

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About This Item

Formula empirica (notazione di Hill):
C24H26BrN3O3
Numero CAS:
27848-84-6
Peso molecolare:
484.39
Numero MDL:
MFCD00869626
Codice UNSPSC:
41116107
ID PubChem:
329831388
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

nicergoline

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC

InChI

1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
YSEXMKHXIOCEJA-FVFQAYNVSA-N

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Nicergoline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Consigli di prudenza

P301 + P312 + P330

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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A Moretti
Arzneimittel-Forschung, 29(8a), 1213-1223 (1979-01-01)
The effects of 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol(5-bromonicotinate) (nicergoline, Sermion) on the energy metabolism in the animal CNS during and after cerebral hypoxia and ischemia have been studied by various authors by different methodological approaches. For this purpose both electrophysiological (EEG and cortically
Treatment of impaired cognition with nootropic drugs: nicergoline versus the state of the art.
R G Fariello
Functional neurology, 12(3-4), 221-225 (1997-05-01)
M Fioravanti et al.
The Cochrane database of systematic reviews, (4)(4), CD003159-CD003159 (2001-11-01)
Nicergoline is an ergot derivative currently in use in over fifty countries for more than three decades, for the treatment of cognitive, affective, and behavioral disorders of older people. It was initially considered as a vasoactive drug and mainly prescribed
Bengt Winblad et al.
Clinical drug investigation, 28(9), 533-552 (2008-08-01)
The ergot alkaloid derivative nicergoline became clinically available about 35 years ago in the 1970s. Nicergoline has a broad spectrum of action: (i) as an alpha(1)-adrenoceptor antagonist, it induces vasodilation and increases arterial blood flow; (ii) it enhances cholinergic and
A Moretti et al.
Arzneimittel-Forschung, 29(8a), 1223-1227 (1979-01-01)
10-Methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) shows a strong alpha-blocking activity both in vitro and in vivo. Various studies (dog, cat, rabbit, rat, mouse, guinea-pig) show that nicergoline affects only slightly blood pressure and heart rate and increases the blood flow in
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