PHR1540
Letrozole
Pharmaceutical Secondary Standard; Certified Reference Material
Sinonimo/i:
Letrozole, 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
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About This Item
Formula empirica (notazione di Hill):
C17H11N5
Numero CAS:
Peso molecolare:
285.30
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24
Prodotti consigliati
Grado
certified reference material
pharmaceutical secondary standard
Livello qualitativo
agenzia
traceable to Ph. Eur. Y0000685
traceable to USP 1356971
Famiglia di API
letrozole
CdA
current certificate can be downloaded
Confezionamento
pkg of 1 g
tecniche
HPLC: suitable
gas chromatography (GC): suitable
applicazioni
pharmaceutical (small molecule)
Formato
neat
Temperatura di conservazione
2-30°C
Stringa SMILE
N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI
1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
HPJKCIUCZWXJDR-UHFFFAOYSA-N
Informazioni sul gene
human ... CYP19A1(1588)
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Descrizione generale
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer.
Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer.
Applicazioni
Letrozole may be used as a pharmaceutical reference standard for the determination of the analyte in biological/environmental samples and pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Azioni biochim/fisiol
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
Risultati analitici
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Altre note
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Nota a piè di pagina
To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive.
Prodotti consigliati
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Repr. 2 - STOT RE 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Certificati d'analisi (COA)
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I clienti hanno visto anche
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Adina Dumitrescu et al.
Endocrinology, 155(12), 4774-4784 (2014-09-24)
We have previously shown that estrogen selectively suppresses growth of the fetal zone of the baboon fetal adrenal cortex, which produces the C19-steroid precursors, eg, dehydroepiandrosterone sulfate, which are aromatized to estrogen within the placenta. In the present study, we
Kelley M Kidwell et al.
Cancer, 120(16), 2403-2411 (2014-05-08)
Aromatase inhibitor (AI) therapy results in substantial survival benefits for patients with hormone receptor-positive breast cancer. The rates of poor adherence and discontinuation of AI therapy are high, primarily because of treatment-related toxicities like musculoskeletal pain. Although pain-related symptoms may
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