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V0033000

Valproic acid

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

2-Propylpentanoic acid, Valproic acid

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About This Item

Formula condensata:
(CH3CH2CH2)2CHCO2H
Numero CAS:
99-66-1
Peso molecolare:
144.21
Numero MDL:
MFCD00002672
Codice UNSPSC:
41116107
ID PubChem:
329828882
NACRES:
NA.24

Grado

pharmaceutical primary standard

agenzia

EP Reference Standard

Famiglia di API

valproic acid

Produttore/marchio commerciale

EDQM

Indice di rifrazione

n20/D 1.425 (lit.)

P. eboll.

220 °C (lit.)

Densità

0.9 g/mL at 25 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
NIJJYAXOARWZEE-UHFFFAOYSA-N

Informazioni sul gene

human ... ALDH5A1(7915)

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Valproic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H318,H360FD

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

231.8 °F - closed cup

Punto d’infiammabilità (°C)

111 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number

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USP

USP

1708718

Valproic Acid Related Compound B

Valpromide ≥97% (NMR)

Sigma-Aldrich

V3640

Valpromide

Phenytoin European Pharmacopoeia (EP) Reference Standard

P1290000

Phenytoin

SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

Valproic Acid-D6 solution 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-029

Valproic Acid-D6 solution

Trichostatin A ≥98% (HPLC), from Streptomyces sp.

Sigma-Aldrich

T8552

Trichostatin A

Levetiracetam European Pharmacopoeia (EP) Reference Standard

Y0001253

Levetiracetam

Mattias Linde et al.
The Cochrane database of systematic reviews, 6(6), CD010611-CD010611 (2013-06-26)
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an
Ivana Rosenzweig et al.
Neuroscience and biobehavioral reviews, 36(8), 1848-1856 (2012-06-02)
Neuropsychiatric medications that directly alter the epigenome, such as valproic acid, can under certain conditions reactivate critical developmental periods and thus impact adult neuroconnectivity. In animal models valproic acid was shown to inhibit the process of postnatal myelination and to
Florence I Roullet et al.
Neurotoxicology and teratology, 36, 47-56 (2013-02-12)
Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over the past 40 years have shown that exposure to VPA in utero is associated with birth defects, cognitive deficits, and increased risk of autism. Two recent
Radu M Nanau et al.
Clinical biochemistry, 46(15), 1323-1338 (2013-06-25)
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic profiles, as well as a relatively favorable safety profile. However, adverse drug reactions have been reported in relation with
Periyasamy Palsamy et al.
Experimental eye research, 121, 26-34 (2014-02-15)
Recent epidemiological studies confirm the prevalence of cataract in epileptic patients. Similarly, the drugs used to treat epilepsy also show the connection with increased cataract formation. In this present study, we investigated the suppression of Nrf2/Keap1 dependent antioxidant protection through
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