PHR1546

Cloruro di acetilcolina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: ACh
• Formula condensata: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• Numero CAS: 60-31-1
• Peso molecolare: 181.66
• Beilstein: 3571875
• Numero CE: 200-468-8
• Numero MDL: MFCD00011698
• Codice UNSPSC: 41116107
• ID PubChem: 329823455
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to Ph. Eur. Y0000002; traceable to USP 1008501
• Famiglia di API: acetylcholine
• CdA: current certificate can be downloaded
• Confezionamento: pkg of 500 mg
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Punto di fusione: 146-150 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1; JUGOREOARAHOCO-UHFFFAOYSA-M
• Informazioni sul gene: human ... CHRM3(1131)

Descrizione

Descrizione generale

Acetylcholine chloride is a stable cholinergic agonist with muscarinic and nicotinic actions.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Acetylcholine chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical preparation using high-performance liquid chromatography/electrospray ionization mass spectrometry.

Azioni biochim/fisiol

Il cloruro di acetilcolina, iniettata in ragione di 20 mg/kg di peso corporeo, riduce la mortalità e le citochine proinfiammatorie nel plasma di topi con sepsi indotte sperimentalmente. Il meccanismo anti-infiammatorio colinergico è probabilmente mediato dalla interazione della acetilcolina con il ricettore colinico α7n su monociti, macrofagi e neutrofili che diminuisce i livelli delle citochine proinfiammatorie come TNF-α, IL-1β e IL-6.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAB0912 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable