PHR1079

Tobramicina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: Nebramicina Fattore 6, O-[3-amino-3-deossi-α-D-glucopiranosil-(1→6)]-O-[2,6-diamino-2,3,6-trideossi-α-D-riboesopiranosil-(1→4)]-2-deossi-D-streptamina
• Formula empirica (notazione di Hill): C₁₈H₃₇N₅O₉
• Numero CAS: 32986-56-4
• Peso molecolare: 467.51
• Beilstein: 1357507
• Numero CE: 251-322-5
• Numero MDL: MFCD00077885
• Codice UNSPSC: 41116107
• ID PubChem: 329823102
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to BP 333; traceable to Ph. Eur. T1500000; traceable to USP 1667508
• Famiglia di API: tobramycin
• CdA: current certificate can be downloaded
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1; NLVFBUXFDBBNBW-SNGYORCQSA-N

Descrizione

Descrizione generale

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tobramycin is an aminoglycoside antibiotic effective in treating infections caused by Gram negative bacteria.

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tobramycin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high performance liquid chromatography.

Azioni biochim/fisiol

La tobramicina è un aminoglicoside.
Modalità d′azione: Si lega alla subunità ribosomiale 70S, inibisce la traslocazione e suscita errori di codifica.
Spettro di attività: Batteri gram negativi. Non efficace nei confronti di Enterococci.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA5713 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H361f
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3