21186

Calcium ionophore III

Selectophore^™, function tested

• Sinonimo/i: Antibiotic A 23187, Calimycin
• Formula empirica (notazione di Hill): C₂₉H₃₇N₃O₆
• Numero CAS: 52665-69-7
• Peso molecolare: 523.62
• Beilstein: 1096801
• Numero CE: 258-084-1
• Numero MDL: MFCD00151202
• Codice UNSPSC: 26111700
• ID PubChem: 329752113
• NACRES: NB.61

Proprietà

• Grado: for ion-selective electrodes
• Livello qualitativo: 200
• Nome Commerciale: Selectophore^™
• Forma fisica: solid
• Qualità: function tested
• Spettro attività antibiotica: Gram-positive bacteria; fungi
• Modalità d’azione: cell membrane | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1; HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Descrizione

Descrizione generale

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Applicazioni

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Note legali

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves