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Documenti fondamentali

MAB1676

Sigma-Aldrich

Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205

clone TA205, Chemicon®, from mouse

Sinonimo/i:

Anti-ILWEQ, Anti-TLN, Anti-talin-1

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

TA205, monoclonal

Reattività contro le specie

rabbit, human

Non deve reagire con

mouse, rat

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TLN1(7094)

Specificità

Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility.

Immunogeno

Epitope: N-terminus, a.a. 139-433

Applicazioni

Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
Immunoblotting, recognizes a band at ~230kDa.

Immunoprecipitation

Immunofluorescence

Optimal working dilutions must be determined by end user.

Stato fisico

Format: Purified
Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.

Stoccaggio e stabilità

Maintain between 2 and 8°C for up to six months.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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D C Love et al.
Experimental parasitology, 88(3), 161-171 (1998-04-30)
In the present study, we examine the cell biology of Leishmania amastigote uptake by mammalian cells and compare this process to the phagocytosis of IgG-opsonized erythrocytes. We report that many aspects of amastigote uptake into macrophages resemble classical receptor-mediated phagocytosis.
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the ?1 integrin-RACK1 axis.
Trerotola, M; Li, J; Alberti, S; Languino, LR
Journal of Cellular Physiology null
Li-Ting Su et al.
The Journal of biological chemistry, 281(16), 11260-11270 (2006-01-27)
m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not well understood, particularly because the dependence of calpain on calcium exceeds the
S J Bolton et al.
Cell motility and the cytoskeleton, 36(4), 363-376 (1997-01-01)
We have characterized a panel of 6 monoclonal antibodies raised against human platelet talin by Western blotting, immune precipitation, and immunofluorescence, and shown that antibodies TA205 and TD77 disrupt actin stress fibers and focal adhesions, and inhibit cell motility when
Jaron Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), E4864-E4873 (2015-08-19)
Insight into how molecular machines perform their biological functions depends on knowledge of the spatial organization of the components, their connectivity, geometry, and organizational hierarchy. However, these parameters are difficult to determine in multicomponent assemblies such as integrin-based focal adhesions

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