AB10545

Anti-TIGAR Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: chromosome 12 open reading frame 5, TP53-induced glycolysis and apoptosis regulator, transactivated by NS3TP2 protein, probable fructose-2,6-bisphosphatase TIGAR
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: mouse, human, rat
• Reattività contro le specie (prevista in base all’omologia): bovine (based on 100% sequence homology)
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• N° accesso NCBI: NP_065108
• N° accesso UniProt: Q9NQ88
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TIGAR(57103)

Descrizione

Descrizione generale

TIGAR (TP53-induced glycolysis and apoptosis regulator) is a p53-inducible protein that is thought to diminish levels of reactive oxygen species (ROS) and this may also contribute to p53 protecting from genomic damage. TIGAR’s ability to lower ROS levels may also have an important role to play in the autophagic response. It is known to decrease levels of fructose-2,6-bisphosphate and in turn inhibits glycolysis. Under ischemic stress, recent research has shown that TIGAR and p53 can regulate cellular energy homeostasis and apoptosis.

Immunogeno

KLH-conjugated linear peptide corresponding to human TIGAR.

Applicazioni

Anti-TIGAR Antibody is an antibody against TIGAR for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:400 dilution from a previous lot detected TIGAR in normal human brain and glioblastoma cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualità

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected TIGAR in 10 µg of HeLa cell lysate.

Descrizione del bersaglio

~30 kDa observed

Stato fisico

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
HeLa cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable