8.08260

Acido trifluoroacetico

for synthesis

• Sinonimo/i: TFA
• Formula condensata: CF₃COOH
• Numero CAS: 76-05-1
• Peso molecolare: 114.02
• Beilstein: 742035
• Numero MDL: MFCD00004169
• Codice UNSPSC: 12352106
• Numero indice EU: 200-929-3

Proprietà

• Densità del vapore: 3.9 (vs air)
• Livello qualitativo: 200
• Tensione di vapore: 97.5 mmHg ( 20 °C)
• Saggio: ≥99% (acidimetric)
• Forma fisica: liquid
• Indice di rifrazione: n20/D 1.3 (lit.)
• pH: 1 (10 g/L in H₂O)
• P. eboll.: 72.4 °C (lit.)
• Punto di fusione: −15.4 °C (lit.)
• Solubilità: soluble 10 g/mL
• Densità: 1.489 g/mL at 20 °C (lit.)
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7); DTQVDTLACAAQTR-UHFFFAOYSA-N

Descrizione

Descrizione generale

Trifluoroacetic acid is widely used in organic synthesis as a solvent, catalyst and reagent. It is a strong acid and low boiling point reagent. It can be used as a catalyst for a variety of reactions such as rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.

Applicazioni

Trifluoroacetic acid can be used as a catalyst

• In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
• In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.

Trifluoroacetic acid can also be used

• In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.

Caratteristiche e vantaggi

Trifluoroacetic acid can be used as a catalyst due to its

• High acidity
• Easy elimination
• Good solubility in organic solvent and in water.

Risultati analitici

Assay (acidimetric): ≥ 99.0 %
Density (d 20 °C/ 4 °C): 1.487 - 1.490
Identity (IR): passes test

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H314 - H332 - H412
• Consigli di prudenza: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Codice della classe di stoccaggio: 8A - Combustible, corrosive hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 212.0 °F - Pensky-Martens closed cup
• Punto d’infiammabilità (°C): > 100 °C - Pensky-Martens closed cup