124038

Akt Inhibitor V, Triciribine

InSolution, ≥95%

• Sinonimo/i: InSolution Akt Inhibitor V, Triciribine
• Formula empirica (notazione di Hill): C₁₃H₁₆N₆O₄
• Numero CAS: 35943-35-2
• Peso molecolare: 320.30
• Numero MDL: MFCD00932413
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −70°C
• Stringa SMILE: [n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
• InChI: 1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1; HOGVTUZUJGHKPL-HTVVRFAVSA-N

Descrizione

Descrizione generale

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Stato fisico

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

Ricostituzione

Following intitial thaw, aliquot and freeze (-70°C).

Altre note

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Punto d’infiammabilità (°C): 87 °C - closed cup - (Dimethylsulfoxide)