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124005

Sigma-Aldrich

Akt Inhibitor

The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinonimo/i:

Akt Inhibitor, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl- sn-glycerocarbonate, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate

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About This Item

Formula empirica (notazione di Hill):
C30H58O10
Peso molecolare:
578.78
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (NMR)

Stato

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated (hygroscopic)

Colore

white to off-white

Solubilità

DMSO: 200 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Descrizione generale

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.

Azioni biochim/fisiol

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 5.0 µM for Akt (PKB)

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Use anhydrous DMSO for reconstitution.

Altre note

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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