05-23-3801

Endothelin 3, Human and Rat

Attenuates thrombin-evoked aggregation of human platelets.

• Sinonimo/i: Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
• Formula empirica (notazione di Hill): C₁₂₁H₁₆₈N₂₆O₃₃S₄
• Numero CAS: 117399-93-6
• Peso molecolare: 2643.04
• Numero MDL: MFCD00076378
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated
• Solubilità: 5% acetic acid: 0.5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ET_A receptors.

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Stimulator of interleukin-6 production by endothelial cell lines

Product does not compete with ATP.

Reversible: no

Confezionamento

Yes

Sequenza

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Stato fisico

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

Nota sulla preparazione

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Altre note

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable